A Proprietary Formulation of Natural and Eco-Certified Ingredients for Better Hair Health
Formula 82S Hair Loss Shampoo is a novel formulation specifically designed to strengthen hair fibers and provide soft and natural texture. With 82S, hair recovers its vitality thanks to a blend of natural extracts like Saw Palmetto to reduce hair loss and Eco-certified cleansing agents, amino acids and vitamins to support hair health. 82S is excellent in combination with
prescription products, such as Formula 82M.
• Natural and eco-certified Ingredients
• Contains restructuring amino acids which stimulate hair fiber growth
• Provides natural cleansing without hair damage
• Nourishes and strengthens hair fibers
• Actively reduces DHT to fight hair loss
• Leaves hair soft, shiny and easy to comb
• Performance validated by scientific studies
• Sulfate, paraben and sodium chloride free
ACTIVE HAIR LOSS PREVENTION
SAW PALMETTO (SERENOA REPENS): A contributing factor in Androgenetic Alopecia is the conversion of Testosterone to Dihydrotestosterone (DHT) via the enzyme 5a Reductase (5AR). Serenoa Repens is a botanically-derived SAR inhibitor that has been shown in studies to have a positive effect in reducing hair loss.
AMINO ACIDS: Strengthen the structure of hair and serve as a precursor to hair growth functions such as cellular metabolism and the synthesis of hair proteins. Our specially formulated Amino Acid compound has been shown in studies to lead to increased tensile strength in hair.
BIOTINE A vital substance for hair health. Stimulates the proliferation of Keratinocytes, and improves hair's natural barrier function by promoting the formation of intercellular lipids and reducing transepidermal water loss.
PHYTOKERATINE: Prevents future damage and returns strength and vitality to damaged hair.
VITAMIN E: A powerful anti-oxidant that prevents and repairs cell and tissue damage. Vitamin E's effectiveness as a hair loss prevention component is well documented—it is commonly advised by physicians to reduce hair loss for people taking chemotherapy drugs such as Doxorubicin.
L-GLUTAMIC AMINO ACID & COCONUT FATTY ACIDS
Eco-certified surfactant that is plant derived and biodegradable. In addition to being an excellent (gentle) cleanser, it exhibits conditioning properties that leaves hair feeling silky.
BABASSU OIL: Eco-certified (70% lipid) vegetable oil with cleansing and foaming properties. Conditions and repairs.
PANTHENOL (PROVITAMIN 5): Readily binds to the hair shalt, assisting hair in increasing and retaining its natural moisture. Helps fortify collagen in hair, promoting elasticity and hair strength.
SEAWEED EXTRACT: A natural source of essential vitamins and minerals as well as antioxidants that aid in skin cell and hair elasticity, and help keep hair and skin revitalized, moisturized and protected. Has natural cleansing and balancing properties linked to the reduction of skin oiliness and sebum production.
A Proprietary Formulation of Natural and Eco-Certified Ingredients for Better Hair Health
Formula 82S is a 3-in-1 (shampoo + conditioner + anti-hair loss) product designed to strengthen hair fibers, and restore soft, natural texture to damaged hair and aid in the prevention of hair loss. It fills in a vital gap for patients undergoing hair restoration in that it contains an industry leading level of DHT-blocking Saw Palmetto, and ensures that clients are using gentle cleansers and not damaging new hair growth through the use of sulfates, parabens, and sodium chloride, found in lower quality shampoos.
Formula 82S formulation is 100% natural, and contains eco-certified cleansers, as well as the active ingredient Saw Palmetto, a natural botanically derived 5-alpha reductase inhibitor shown in studies to reduce DHT production, the leading cause of hair loss. 82S also helps new hair grow stronger and existing hair recover its vitality due to a highly-effective blend of natural extracts, amino acids and vitamins.
Formula 82S was recently updated to increase the amount of Saw Palmetto it contains and its primary surfactant and conditioning ingredients improved, leading to greater sudsing and conditioning, while retaining the core benefits of the formula. Formula 82S leaves hair feeling soft, healthy and easy to comb, without the need for a separate conditioner, and is an excellent complement to a daily regrowth regimen, such as one involving Formula 82M or Formula 82F (for men only).
Helps Reduce DHT to Fight Hair Loss
A major contributing factor in Androgenetic Alopecia (AGA) is the conversion of Testosterone to Dihydrotestosterone (DHT) via the enzyme 5-α Reductase (5AR).
Formula 82S hair loss shampoo contains the active ingredient Serenoa Repens (Saw Palmetto), a natural, botanically-derived 5-alpha reductase inhibitor that has been shown in studies to help reduce DHT production and prevent hair loss.
Dihydrotestosterone (DHT) and Hair Loss
For many years, scientists thought that androgenetic alopecia was caused by the predominance of the male sex hormone, testosterone, which women also have in trace amounts under normal conditions. While testosterone is at the core of the balding process, DHT is thought to be the main culprit. Testosterone converts to DHT with the aid of the enzyme Type II 5-alpha reductase, which is held in a hair follicle's oil glands. Scientists now believe that it's not the amount of circulating testosterone that's the problem, but the level of DHT binding to receptors in scalp follicles. DHT shrinks hair follicles, making it impossible for healthy hair to survive.
McAndrews PJ. "Women's Hair Loss / Causes of Hair Loss". American Hair Loss Association
Balanced Cleansing without Causing Hair Damage
Overview of Terms Used in Hair Products
Surfactants (cleansing agents)
Compounds that lower the surface tension between two liquids, or between a liquid and a solid (typically through sudsing). Surfactants can act as detergents, wetting agents, foaming agents and dispersants. Surfactants perform the cleaning function at the heart of most shampoos.
Absorption (combining, sometimes referred to as penetration)
Process in which one molecule dissolves into another uniformly. Once absorption takes place, it cannot easily be undone; in other words, the two molecules (or groups of molecules) cannot be easily separated.
Adsorption (adhering to). The process in which a molecule adheres to the surface of another, through weak (typically electromagnetic) forces. For example, Humectant molecules attract negatively-charged Oxygen atoms in water. This (-OH) hydrogen bonding promotes the migration and retention of water around the shaft of the hair.
Humectants (also referred to as moisturizers)
Prevent loss of moisture, and in some cases, have the ability to actively attract moisture. Highly effective humectants can adsorp (or attract and hold) up to three times their weight in water.
pH (The measure of acidity of a substance)
Most modern shampoos and conditioners are formulated to be slightly acidic, having a pH around that of the hair’s acid mantle (4.0-5.0). Hair that is close to its ideal pH of 4.5–5.0 is generally considered to be at its peak strength.
Alkaline products typically cause hair to swell, causing the cuticle to lift and remove oils from the air. This results in frizzy, dull, brittle hair that is prone to breakage and tangling. Extremely alkaline solutions cause the disulfide bonds between Keratin protein molecules to break down, and can eventually dissolve the protein completely. These types of solutions are used to perm or relax the hair, and can be extremely damaging, especially to hair that is already fragile.
Sebum (an oily secretion of the sebaceous glands)
Some level of sebum production is healthy and protects skin and hair from environmental damage and prevents dry and cracked skin (including the scalp). However the overproduction and accumulation of sebum can lead to bacteria growth and clogged pores, commonly causing dermatitis, and can negatively affect hair follicles and hair health.
82S contains specially formulated cleansers and conditioners that remove dead skin and build-up and replace vital moisture and oils—in a way that mimics skin and hair’s naturally healthiest state. First, 82S’s pH (~5.2) is very close to that of healthy hair’s mantle. Second, the surfactants in 82S are much gentler than the sulfate-based wetting agents found in the majority of shampoos worldwide. The Glutamic Amino Acid-derived & Coconut Fatty Acid-based cleansers found in 82S offer far more balanced cleansing—and remove surface sebum without affecting hair’s intercellular lipids—compared to Sodium Lauryl Sulfate (SLS), Sodium Laureth Sulfate (SLES), and other sulfate-based cleansers prevalently used in shampoos (due to their high availability and low costs).
Natural Conditioners Leave Hair Soft, Shiny and Easy-to-Comb
A lot of thought and specialized ingredients go into making a quality shampoo (let alone an all natural, hair loss shampoo). On one hand, you have little choice but to remove naturally occurring surface lipids that protect the skin and hair if you want to wash your hair. And for the most part it is much better to remove dead skin and built-up oils from hair so that it doesn’t result in clogged pores and greasy, tangled, limp hair. But the simple truth is shampoos (through the surfactants they contain that cleans the hair) all strip components that the hair and scalp produce on their own, and need to a large extent, in order to remain healthy. Namely, naturally produced oils and moisture. Unless you condition at the same time or immediately after cleaning your hair, you will end up with dry, damaged hair. It’s a fact that most shampoos don’t mention on their labels.
The key aspects of hair health, related to hair loss and hair condition, involve the strength and health of the hair’s roots and the promotion of smooth texture of the hair’s shaft. Aside from Androgenic Alopecia (or genetically-predisposed male and female pattern balding), the single greatest cause of hair loss is physical/mechanical damage—specifically, subjecting hair to forces that exceed its natural tensile strength, causing it to break, or exerting forces on hair follicles that over time lead to damage to the roots of hair.
Let’s examine two common issues:
1) You know that flat irons, bleaching, and blow dryers cause physical damage to hair, but did you know that aside from those things, the force on hair’s roots from styling hair in buns, braids and ponytails over time can cause damage to hair—resulting in hair loss? Women who consistently part their hair or wear their hair in ponytails are among the most treated patients at hair loss clinics. You may not think about it, but by putting force on the roots of your hair, you are actively damaging your hair’s follicles (your hair’s life source and anchor).
2) The simple act of combing your hair in the morning is one of the potentially most damaging things you do to your hair all day. The reason to emphasize ‘potentially’ is because if your hair is properly conditioned—so that it adsorbs sufficient moisture and fatty-acids shortly following cleansing—it becomes more combable. And combability (or the ease with which hair can be detangled and styled) is at the heart of what you want in a hair care product. A high-quality shampoo with conditioning agents (or a separate conditioner) should do one thing well: leave your hair untangled, moist and smooth enough that you can style it without causing damage to your hair’s shaft and roots.
Given that most shampoos and conditioners you find on the shelf at stores will leave your hair feeling somewhat smooth, that bar may seem to be a low one, but patients who have already experienced an appreciable degree of hair loss stand to benefit tremendously from the scientifically-proven increased combability and tensile strength from the use of 82S. In laboratory studies involving both colored (treated) and uncolored (untreated) hair, key components of 82S were shown to increase both the tensile strength and wet combability of hair. To fully appreciate what that means to hair’s health, see what the benefit of these ingredients looks like in terms of smoothness and strength of a single shaft of hair at a molecular level, after extensive simulated styling below:
First, 82S’s pH (~5.2) is very close to that of healthy hair’s mantle. Second, the surfactants in 82S are much gentler than the sulfate-based wetting agents found in the majority of shampoos worldwide. The Glutamic Amino Acid-derived & Coconut Fatty Acid-based cleansers found in 82S offer far more balanced cleansing—and remove surface sebum without affecting hair’s intercellular lipids—compared to Sodium Lauryl Sulfate (SLS), Sodium Laureth Sulfate (SLES), and other sulfate-based cleansers prevalently used in shampoos (due to their high availability and low costs).
Contains Amino Acids to Strengthen Hair Fibers
Amino Acids, when interactive and bioavailable can strengthen the structure of hair.
Our specially formulated amino acid complex specifically targets mechanisms shown in studies to lead to increased tensile strength in hair, elasticity, moisture affinity, color retention, and damage prevention. The composition of our Amino Acids complex is modeled after the constituent amino acids of protein in the Cell Membrane Complex (CMC), and is known to provide beneficial protection and improve the health of hair. Formula 82S contains a specially formulated complex of amino acids (including Histidine, Phenylalanine, Arginine, Alanine, Serine, Glycine, Valine, Proline, Threonine, Isoleucine, and Phytokeratine).
Amino Acids in Shampoos and Conditioners
When amino acids are applied to hair in the form of simple aqueous solution, uptake of the amino acids is mainly controlled by ionic equilibrium. When amino acids were incorporated in a hair conditioner, the result was quite different, suggesting the importance of interaction between the amino acids and the cationic surfactants. Uptake of Pyrrolidone Carboxylic Acid (PCA), a derivative of Glutamic Acid, is enhanced by combining with Arginine, an amino with strong affinity towards hair. […] Alanine in a hair conditioner increases hair surface hydrophobicity. Histidine and Phenylalanine improve tensile strength. PCA was proved to be effective to improve color-retention of dyed hair.
Oshimura E (1), Abe H, Oota R. "Hair and amino acids: the interactions and the effects". Journal of Cosmetic Science
Nourishes Hair From Root to Tip
At Hair Science, we understand that the average person undertakes some form of normal daily hair management. We specifically formulated 82S to address the realities of typical-use routines—including combing, styling, and drying your hair. We began the formulation of 82S with the inclusion of Saw Palmetto to reduce DHT, to prevent follicle shrinkage and promote healthy development of hair’s roots. We then added natural conditioning agents to restore moisture and oils to hair’s shaft. And finally, we added a series of Amino Acids to strengthen and improve the combability of hair and protect it from environmental damage.
Amino acids applied externally are known to interact with the hair to produce various cosmetic effects, such as moisturizing, strengthening, color-protection and repair of surface damage (Oshimura).
Alanine is a hydrophobic molecule. It is ambivalent, meaning that it can exist inside or outside of the protein molecule. Hair surface hydrophobicity prevents “frizzy” hair. And restoring this natural characteristic of hair indicates the effectiveness of Alanine in promoting the absorption of nourishing oils to the hair shaft—sealing and protecting them.
Use of 82S would significantly reduce the effects of physical damage of combing hair in just a few months if it contained only the amino acids: Histidine, Phenylalanine, and Arginine. But we also added a number of other nourishing conditioners, amino acids, including the thermal protectant, Phytokeratine, to protect hair from thermal damage encountered from drying as well as from daily environmental exposure to UV.
The use of curling irons and other heat sources, as well as excessive application of hair products such as perms and hair coloring strip the protective layering off the outside of the hair's shaft and weaken the hair, making it prone to split ends. Imbalances in the pH of hair and mechanical stresses—including pulling a comb forcefully through tangled hair, repeated combing, and the use of elastics and other hair retention methods cause damage to hair’s shaft and ends.
In addition to the primary focus of the ingredients found in 82S on hair’s roots and shaft, the inclusion of Phytokeratine and other conditioning agents was made to address Trichoptilosis, or split ends, which result from thermal, chemical and mechanical stresses to hair.
Characteristics of Amino Acids in Hair Health Promotion (pH)
Basic amino acids improve hair strength and shine
Neutral amino acids improve the dry feel of hair (combability, smoothness and silky feel)
Acidic amino acids improve the wet feel of hair (combability and smoothness)
Sulfate, Paraben and Sodium Chloride Free
Many commonly used hair products contain inexpensive surfactants, known as Sodium Lauryl Sulfate and Sodium Laureth Sulfate (also known as sulfates). Sulfates are effective surfactants, but they are not generally considered to be particularly well-balanced and they cause irritation of the skin and scalp in many people. Sulfate-based products rely on the near complete removal of build-up of your skin’s naturally occurring lipids, which leads to dryness, and creates a cycle in which your skin begins to overproduce sebum as a result.
82S starts out by using surfactants that are as balanced and gentle as possible (more so than essentially every commercially-available shampoo on the market). To counteract the depletion of healthy oils in hair, we include ingredients that help restore the hair’s ability to attract and retain moisture, and condition and coat hair in order to replace natural fatty acids. 82S’s natural conditioners and nourishing agents closely mimic the naturally-occurring oils found in healthy hair and leave hair feeling soft and manageable.
Safe for Color Treated Hair / Promotes Color Retention
Surfactants and conditioners that are mildly acidic have been found to provide longer life to the color of hair that has been dyed. Specifically, the addition of Sodium PCA / Pyrrolidone Carboxylic Acid (which is found in many shampoos that state “For Colored or Treated Hair”) has been shown to improve color retention of dyed hair.
In the above study, color development of red semi-permanent hair dye was shown to be improved by over 80% through the use of post-dye treatment with hair conditioner containing Sodium PCA.
Performance Validated Ingredients in Scientific Studies
Hair Science is first and foremost a research and development company. Our formulas combine well-established ingredients—known to benefit hair and scalp health—with novel formulations and methods that increase their efficacy, stability, and usability. We work with some of the world’s top compounding pharmacies, chemists, and hair experts to ensure that our products are among the safest, most balanced, and most effective on the market.
And unlike many other shampoos and products, we have the certifications, lab tests, and science to back our formulas’ effectiveness claims. Be it 82S’ eco-certification, component tensile strength tests, “color-fast” or wet combability studies, we are happy to match up against other shampoos and providers. As we have complete confidence in the fact that we offer some of the best hair care products available in the world today.